This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Corr, P. J. Articles by Kumari, V. Search for Related Content PubMed PubMed Citation Articles by Corr, P. J. Articles by Kumari, V. Social Bookmarking                         What's this?

Individual differences in mood reactions to d-amphetamine: a test of three personality factors

Department of Psychology, Goldsmiths College, University of London, London, SE14 6NW, UK; p.corr{at}gold.ac.uk

Veena Kumari

Section of Cognitive Psychopharmacology, Division of Psychological Medicine, University of London, Institute of Psychiatry, University of London, De Crespigny Park, London, UK

Individual differences in self-reported mood following either 5 mg or 10 mg d-amphetamine challenge were examined in order to test the modifying role of three factors of personality, viz., the Eysencks' psychoticism, Cloninger's novelty seeking, and Depue and Collins' extraversion. In a double-blind study, mood measures (energetic arousal, tense arousal, and hedonic tone) were taken immediately following a single-dose of d-amphetamine and then again after 90 min. The results showed significant psychoticism x d–amphetamine interactions for both drug doses: d-amphetamine increased energetic arousal and hedonic tone, and reduced tense arousal, only in low psychoticism individuals; in high psychoticism individuals, it led to lowered energetic arousal and hedonic tone, and increased tense arousal. Neither novelty seeking nor extraversion modified the effects of d-amphetamine. These data suggest a link between psychoticism and dopaminergic functioning, although they do not rule out the involvement of other transmitter systems (e.g. noradrenergic). In common with other studies, such findings point to the important role that well-established factors of personality play in accounting for individual differences in reactions to psychoactive drugs. It is concluded that the routine inclusion of personality measures in future psychopharmacological studies may help to refine the characterization of drug effects.

Key Words: amphetamine • extraversion • individual differences • mood • novelty seeking • paradoxical effects • psychosis-proneness • psychoticism • substance abuse

Journal of Psychopharmacology, Vol. 14, No. 4, 371-377 (2000)
DOI: 10.1177/026988110001400406


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?