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The analgesic effects of selective serotonin reuptake inhibitors

Andrew J. Smith

Liaison Psychiatry Department, Box 175, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK. Present address: Consultant Psychiatrist, Barrow Hospital, Bristol BS43 3S9, UK

This paper endeavours to provide a critical clinical review of the use of selective serotonin reuptake inhibitors (SSRIs) in the management of pain. Case reports, placebo-controlled trials and trials comparing SSRIs with tricyclic antidepressants (TCAs) are considered. The analgesic effects of TCAs are well known and this review suggests that there is little evidence for their replacement by SSRIs in pain management. There are, at present, too few comparative drug trials to make a definitive statement, although the trend is clearly against SSRIs.

Key Words: analgesia • citalopram • fluoxetine • fluvoxamine • paroxetine • SSRIs • sertraline • tricyclic antidepressants

Journal of Psychopharmacology, Vol. 12, No. 4, 407-413 (1998)
DOI: 10.1177/026988119801200413
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