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Journal of Psychopharmacology
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Effect of venlafaxine on pineal melatonin and noradrenaline in the male rat

M. Franklin

University of Oxford Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK

E.M. Clement

University of Oxford Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK

G. Campling

University of Oxford Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK

P.J. Cowen

University of Oxford Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK

Studies in vitro indicate that the antidepressant drug, venlafaxine (VEN), inhibits the reuptake of both serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NA) but has little activity on other neurotransmitter receptors. There are, however, few studies on the effects of VEN on monoamine neurotransmission in vivo. In the present study we examined the effect of VEN treatment on the melatonin content of the rat pineal gland because the synthesis of melatonin is regulated by the release of NA onto pinealocyte ß-adrenoceptors. Acute treatment with higher doses (15 mg/kg) of VEN significantly increased pineal melatonin and NA but this effect was attenuated by subchronic treatment. These data are consistent with in vitro data suggesting that VEN increases NA neurotransmission at higher doses and that repeated treatment can desensitize pinealocyte ß-adrenoceptors.

Key Words: melatonin • noradrenaline • pineal • venlafaxine

Journal of Psychopharmacology, Vol. 12, No. 4, 371-374 (1998)
DOI: 10.1177/026988119801200407
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