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Journal of Psychopharmacology
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*ATROPINE
*NICOTINE
*NICOTINE TARTRATE
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Nicotine potentiates sulpiride-induced catalepsy in mice

M.R. Zarrindast

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences and Soha Research and Development Center, Karaj, 52 KM Tehran-Ghazvin HWY, Iran

F. Haeri-Zadeh

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences and Soha Research and Development Center, Karaj, 52 KM Tehran-Ghazvin HWY, Iran

A. Zarghi

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences and Soha Research and Development Center, Karaj, 52 KM Tehran-Ghazvin HWY, Iran

P. Lahiji

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences and Soha Research and Development Center, Karaj, 52 KM Tehran-Ghazvin HWY, Iran

The effects of nicotine on sulpiride-induced catalepsy in mice were investigated. Sulpiride (12.5-100 mg/kg) induced a low degree of catalepsy in mice which was dose dependent. Nicotine (0.0001-1 mg/kg) caused an even lower degree of catalepsy. When the drugs were co-administered a much higher cataleptogenic response was obtained. The potentiation of the effect of sulpiride by nicotine was elicited by 0.5 mg/kg or higher doses of the drug. The central nicotinic receptor antagonist mecamylamine (1-3 mg/kg) and the peripheral antagonist hexamethonium (5 and 10 mg/kg) decreased the response induced by the combination of nicotine and sulpiride. Higher doses of the cholinoceptor antagonist atropine (10 mg/kg) also reduced the catalepsy induced by the drug combination. It is concluded that nicotine potentiates sulpiride-induced catalepsy through activation of cholinergic mechanism(s) and that the central nicotinic mechanism mediates nicotine's action.

Key Words: atropine • catalepsy • mice • nicotine antagonists • nicotine • sulpiride

Journal of Psychopharmacology, Vol. 12, No. 3, 279-282 (1998)
DOI: 10.1177/026988119801200308
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