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Journal of Psychopharmacology
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Comparison of effects of a range of 5 -HT receptor modulators on consumption and preference for a sweetened ethanol solution in rats

Jordi S. Silvestre

Research Centre, Laboratorios, Almirall, S.A., Cardener 68-74, Barcelona 08024, Spain

José M. Palacios

Research Centre, Laboratorios, Almirall, S.A., Cardener 68-74, Barcelona 08024, Spain

Andres G. Fernandez

Research Centre, Laboratorios, Almirall, S.A., Cardener 68-74, Barcelona 08024, Spain

Michael F. O'Neill

Research Centre, Laboratorios, Almirall, S.A., Cardener 68-74, Barcelona 08024, Spain

This study assessed the effects of a range of serotonergic agents on preference for a slightly sweetened ethanol solution (10% ethanol, 3% glucose) in rats. A two-bottle, free-choice paradigm was used following induction of ethanol consumption. The model used provides a robust and reliable level of ethanol self-administration in normal laboratory rats. Ethanol consumption was significantly and selectively reduced by the 5- hydroxytryptamine-1A (5-HT1A) full agonist 8-OH-DPAT (0.3-1.0 mg/kg) and the 5-HT 3 antagonist granisetron (0.1-1.0 mg/kg). Non-specific reductions in fluid consumption were induced by the 5-HT1B agonist RU 24969 (0.1- 1.0 mg /kg) and the 5-HT2 antagonist ritanserin (1.0-6.0 mg/kg). These studies thus confirm the potential for decreasing ethanol consumption and ethanol preference of 5-HT 1A agonists and 5-HT3 antagonists, but failed to find any selective effects for agents acting at 5-HT1B or 5-HT2 receptors.

Key Words: buspirone • 8-OH-DPAT • ethanol preference • granisetron • rat • ritanserin • RU 24969 • serotonin

Journal of Psychopharmacology, Vol. 12, No. 2, 168-176 (1998)
DOI: 10.1177/026988119801200209
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