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Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior

Study 2 - The effects on behavior of block of NMDA receptors prior to injection of FG-7142

Department of Psychology, Memorial University, St. John's, Newfoundland A1B 3X9, Canada

The hypothesis that N-methyl-D-aspartate (NMDA) receptors mediate initiation of lasting behavioral changes induced by the anxiogenic ß-carboline, FG-7142, was supported in this study. Behavioral changes normally induced by FG-7142 were blocked when the competitive NMDA receptor blocker, 7-amino-phophono-heptanoic acid, was given prior to administration of FG-7142. When cats were subsequently given FG-7142 alone, the drug produced lasting behavioral changes like those reported previously. Flumazenil, a benzodiazepine receptor antagonist, reversed an increase in defensiveness produced by FG-7142 alone, replicating previous findings. The data are consistent with the hypothesis that NMDA-dependent long-term potentiation in limbic pathways subserving defensive response to threat mediates lasting increases in defensiveness produced by FG-7142.

Key Words: Amygdala • anxiety • FG-7142 • LTP • medial hypothalamus • NMDA • periacqueductal gray • post- traumatic stress disorder • stress

Journal of Psychopharmacology, Vol. 12, No. 2, 129-136 (1998)
DOI: 10.1177/026988119801200203


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				R. E. Adamec Evidence that long-lasting potentiation in limbic circuits mediating defensive behaviour in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of benzodiazepine receptors J Psychopharmacol, July 1, 2000; 14(4): 307 - 322. [Abstract] [PDF]

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