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Journal of Psychopharmacology
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What's this?

A naturalistic study of home detoxification from opiates using lofexidine

A.S. Brown

Wolston Park Hospital, Wacol 4076, Queensland, Australia

P.M. Fleming

Portsmouth City Drugs Service, Northern Road Clinic, Northern Road, Cosham, Portsmouth PO6 3EP, UK

The study describes the outcome of home detoxification from opiates using lofexidine, a centrally-acting {alpha} 2 adrenergic agonist, in a consecutive series of 28 unselected individuals. Eleven detoxifications (39%) were successful and 17 (61%) unsuccessful. No major medical or psychological problems were reported. Successful outcome was associated with not using heroin, good compliance with a methadone programme and prediction of success by the key worker. Home detoxification using lofexidine appears to be a useful treatment for some opiate-dependent individuals, and is most likely to be successful in those individuals whose drug use is already well-controlled.

Key Words: detoxification • heroin • lofexidine • methadone • opiate dependence • outpatient

Journal of Psychopharmacology, Vol. 12, No. 1, 93-96 (1998)
DOI: 10.1177/026988119801200112
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This article has been cited by other articles:


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H. Niederhofer, W. Staffen, and A. Mair
A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder
J Psychopharmacol, January 1, 2003; 17(1): 113 - 119.
[Abstract] [PDF]


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