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Effects of (-)eticlopride and 7-OH-DPAT on the tail-suspension test in mice

Department of Biomedical Sciences, Division of Pharmacology, University of Modena, via G. Campi 287, 41100 Modena, Italy

D. Giuliani

Department of Biomedical Sciences, Division of Pharmacology, University of Modena, via G. Campi 287, 41100 Modena, Italy

The dopamine (DA) D ₂/D₃ antagonist (-)eticlopride (0.02, 0.05 and 0.1 mg/kg), dose-dependently increased immobility in the mouse tail-suspension test. Chronic treatment with the same compound (0.05, 0.1 mg/kg, x 14 days) produced a different effect, decreasing immobility when animals were tested 24 h after the last injection. The DA D₃ agonist, 7-OH-DPAT, acutely administered before the same test, behaved biphasically, increasing and decreasing mice immobility at low (0.05 and 0.1 mg/kg) and high (1 and 2 mg/kg) doses, respectively. Chronically administered 7-OH-DPAT reduced the immobility time at 2 mg/kg but not at 0.1 mg/kg. These effects, coupled with measurements of locomotor activity and evaluation of mice behaviour in different conditions, are discussed in the light of putative DA involvement in depressive states and are considered as predicting antidepressant potential.

Key Words: antidepressants • dopamine receptors • (-)eticlopride • 7-OH-DPAT • tail-suspension test

Journal of Psychopharmacology, Vol. 11, No. 4, 339-344 (1997)
DOI: 10.1177/026988119701100409


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