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Kamin blocking is not disrupted by amphetamine in human subjects

School of Psychology, University of Wales Cardiff, PO Box 901, Cardiff CF1 3YG, UK

A.D. Pickering

Department of Psychology, St George's Hospital Medical School, London SW17 ORE, UK

J.A. Gray

Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK

S.H. Jones

Rochdale Healthcare NHS Trust, Department of Clinical Psychology, Birch Hill Hospital, Rochdale OL12 9QB, UK.

S. Abrahams

Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK

D.R. Hemsley

Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK

The effect of oral amphetamine administration on the Kamin-blocking effect in healthy volunteer subjects was investigated. Against predictions, Kamin blocking was not disrupted by either a high or low oral dose of D-amphetamine under conditions which have, in previous studies, led to disruption of a related learning phenomenon (latent inhibition). This lack of effect of amphetamine administration upon Kamin blocking weakens hypotheses that this cognitive process is mediated by the same changes in dopaminergic activity which affect latent inhibition. Currently, the only data which show strong comparative associations between Kamin blocking and latent inhibition are when they are applied to schizophrenic populations. These results may suggest that Kamin blocking and latent inhibition may be measuring different aspects of schizophrenic cognitive dysfunction.

Key Words: amphetamine • Kamin-blocking effect • schizophrenia

Journal of Psychopharmacology, Vol. 11, No. 4, 301-311 (1997)
DOI: 10.1177/026988119701100404


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