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Journal of Psychopharmacology
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Reviews : Antisense oligonucleotides in psychopharmacology and behaviour: promises and pitfalls

E.S.J. Robinson

Psychopharmacology Unit, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK

D.J. Nutt

Psychopharmacology Unit, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK

H.C. Jackson

Knoll Pharmaceuticals Research and Development, Nottingham NG1 1GF, UK

A.L. Hudson

Psychopharmacology Unit, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK

Antisense oligonucleotides are used to study the expression and function of a diverse range of proteins. Areas for which antisense has been used for pharmacological investigation include receptors, neuropeptides and immediate early genes, particularly when specific ligands or markers are not yet available. Antisense oligonucleotides target a specific mRNA and block the expression of the protein by sequence specific hybridization. This technique has not only been shown to be a valuable pharmacological tool but also to have potential therapeutic applications. In this review we discuss the technology behind the technique including developments in methodology employed in antisense experiments. Although antisense provides a novel and highly specific tool, the reliability of the technique and many of the problems associated with antisense experiments are discussed. The main focus of this article is the use of antisense in psychopharmacology to investigate behavioural changes following antisense-mediated inhibition of the expression of specific brain proteins and receptors.

Key Words: antisense oligonucleotides • behavioural pharmacology • brain receptors • gene inhibition; messenger RNA

Journal of Psychopharmacology, Vol. 11, No. 3, 259-269 (1997)
DOI: 10.1177/026988119701100310
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