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Frontal-subcortical circuits: the anatomic basis of executive, social and motivated behaviors

Department of Neurology and Biobehavioral Sciences UCLA School of Medicine and the Behavioral Neurosciences Section, Psychiatry Service, West Los Angeles Veterans Affairs Medical Center, Los Angeles, CA, USA

Jeffrey L. Cummings

Department of Neurology and Psychiatry and Biobehavioral Sciences UCLA School of Medicine and the Behavioral Neurosciences Section, Psychiatry Service, West Los Angeles Veterans Affairs Medical Center, Los Angeles, CA, USA

A series of discrete, parallel frontal-subcortical circuits have been demonstrated to link specific areas of the frontal lobe to areas within the basal ganglia and thalamus. A variety of circuit-specific behaviors can be described involving the dorsolateral prefrontal, orbitofrontal and anterior cingulate circuits. Interruptions or imbalance occurring at various levels within these closed looped circuits is felt to underlie the characteristic behavioral patterns seen. The intricate neurochemical arrangement of the striatum and the complex neurotransmitter interactions that occur within these key subcortical structures form the basis for modulatory influences that can affect these circuits.

Key Words: dopamine • frontal-subcortical circuits • matrix • receptors • striatum • striosomes

Journal of Psychopharmacology, Vol. 11, No. 2, 107-114 (1997)
DOI: 10.1177/026988119701100203


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