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Role of D1 and 1 receptors in the enhanced locomotor response to dopamine D2-like receptor stimulation induced by repeated electroconvulsive shock

Department of Psychology, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK

Maria Collu

Dipartimento di Neuroscienze 'B. B. Brodie', Università di Cagliari

Gian Luigi Gessa

Dipartimento di Neuroscienze 'B. B. Brodie', Università di Cagliari

Gino Serra

Dipartimento di Scienze del Farmaco, Università di Sassari, Via Muroni 23/A, I-07100 Sassari, Italy

We previously reported that, in rats chronically treated with the antidepressant drug imipramine, the enhanced locomotor response to the D₂-like receptor agonist quinpirole became less sensitive to the inhibitory effect of the D₁ receptor antagonist SCH 23390 and more sensitive to the inhibitory effect of the ₁ receptor antagonist prazosin. In this study, we show that in electroconvulsive shock-treated rats these antagonists behave in the opposite manner to that observed in imipramine-treated rats, with SCH 23390 being highly effective and prazosin ineffective in antagonizing the locomotor response to quinpirole. The possibility that these differences may reflect some of the clinical characteristics of these antidepressant treatments is discussed.

Key Words: 1 receptors • antidepressant drugs • D1 and D2 receptors • dopamine • electroconvulsive shock; locomotor activity

Journal of Psychopharmacology, Vol. 11, No. 1, 41-44 (1997)
DOI: 10.1177/026988119701100112


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