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Journal of Psychopharmacology
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Enhanced GABAb receptor-mediated transmission in alcohol-dependence syndrome

Shiona Macdonald

Argyll and Bute Hospital, Lochgilphead, Argyll PA318LD

Frank M. Corrigan

Argyll and Bute Hospital, Lochgilphead, Argyll PA318LD

David F. Gaskell

Argyll and Bute Hospital, Lochgilphead, Argyll PA318LD

Michael French

Institute of Terrestrial Ecology, Abbots Ripton, Huntingdon, Cambridgeshire, UK

We have studied the GABAb receptor-mediated neurotransmissions of alcoholic patients by administering baclofen 10 mg orally and measuring the growth hormone (GH) response. There was a minimal GH response to the baclofen in one of eight control subjects and a greater GH response in 11 of the 16 alcoholic patients. There is thus evidence for increased transmission at the GABAb receptor in detoxified patients with alcohol-dependence syndrome.

Key Words: alcoholism • GABAb • baclofen • growth hormone • caesium

Journal of Psychopharmacology, Vol. 10, No. 4, 321-323 (1996)
DOI: 10.1177/026988119601000412
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