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A comparative trial use of sulpiride and risperidone in Huntington's disease: a pilot study

Department of Psychiatry, Robert Kilpatrick Clinical Sciences Building, Faculty of Medicine, University of Leicester, Leicester LE2 7LX, UK

S.M. Dursun

Department of Psychiatry, Robert Kilpatrick Clinical Sciences Building, Faculty of Medicine, University of Leicester, Leicester LE2 7LX, UK

H. Andrews

Department of Psychiatry, Robert Kilpatrick Clinical Sciences Building, Faculty of Medicine, University of Leicester, Leicester LE2 7LX, UK

Sulpiride and risperidone treatment significantly improved the abnormal involuntary movements of two patients with Huntington's disease on both actometer and clinical assessments. However, treatment with risperidone, but not sulpiride, significantly improved the functional activities as assessed by the Functional Disability Scale. To the best of our knowledge this is the first report of the successful treatment of Huntington's disease with risperidone.

Key Words: Huntington's disease • risperidone • sulpiride • actometer • AIMs • functional disability • case report

Journal of Psychopharmacology, Vol. 10, No. 2, 162-165 (1996)
DOI: 10.1177/026988119601000213


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