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Journal of Psychopharmacology
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Alterations of bromocriptine-induced penile erection by chronic lithium in rats

M. Sharifzadeh

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences

A.R. Dehpour

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences

M. Samini

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences

H. Hassan-Mazandarani

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences

T. Samadian

Department of Pharmacology, Darou-Pakhsh Pharmaceutical Research Center, Tehran, Iran

Gh. R. Asghari

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences

In the present study, the effects of chronic lithium pre-treatment (30 days) on penile erection (PE) induced by bromocriptine were investigated in rats. Intraperitoneal administration of the dopamine receptor agonist, bromocriptine (4-32 mg/kg) induced PE in a biphasic manner. The maximum response was obtained with 8 mg/kg of bromocriptine and the effect was decreased with increasing doses of the drug from 8 to 32 mg/kg. When animals were pre-treated with different doses of the D-1 dopamine receptor antagonist, SCH 23390, or the D-2 dopamine receptor antagonist, sulpiride, the PE response was decreased. The response induced by bromocriptine (4-32mg/kg) was reduced in animals pre-treated with chronic lithium. SCH 23390 did not produce a larger inhibitory effect on the bromocriptine response in animals pre-treated with chronic lithium, but the inhibitory effect of sulpiride was increased in this condition. It is concluded that chronic lithium treatment may alter the D-1/D-2 receptor activity and inhibit bromocriptine-induced PE.

Key Words: bromocriptine • SCH 23390 • sulpiride • lithium • dopamine receptors • penile erection • rat

Journal of Psychopharmacology, Vol. 10, No. 2, 157-161 (1996)
DOI: 10.1177/026988119601000212
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