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Journal of Psychopharmacology
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The effect of chlorpromazine and benzhexol on memory and psychomotor function in healthy volunteers

N. Quigley

Department of Therapeutics and Pharmacology, The Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK

D. Morgan

Department of Therapeutics and Pharmacology, The Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK

C. Idzikowski

Department of Therapeutics and Pharmacology, The Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK

D.J. King

Department of Therapeutics and Pharmacology, The Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK

Both antipsychotic and anticholinergic drugs have been implicated in the production of the memory deficits seen in schizophrenia. We compared the effects of chlorpromazine (50 mg) and benzhexol (5 mg) with placebo on a battery of tests of memory, psychomotor function and mood, in 12 healthy volunteers. Benzhexol, but not chlorpromazine, impaired both word recall and word recognition. Neither drug had an effect on long-term memory Both active compounds were associated with self-rated sedation, and chlorpromazine produced impairment in saccadic eye movements. This study supports the contention that sedation is unlikely to be the mechanism by which anticholinergic drugs exert their amnestic effect.

Key Words: antipsychotics • anticholinergics • memory • psychomotor performance • eye movements • healthy volunteers

Journal of Psychopharmacology, Vol. 10, No. 2, 146-152 (1996)
DOI: 10.1177/026988119601000210
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