SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Journal of Psychopharmacology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Fink-Jensen, A.
Right arrow Articles by Nielsen, E. B.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Fink-Jensen, A.
Right arrow Articles by Nielsen, E. B.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Regional differences in the effect of haloperidol and atypical neuroleptics on interstitial levels of DOPAC in the rat forebrain: an in vivo microdialysis study

Anders Fink-Jensen

Health Care Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Mådløv, Denmark

Liselotte Hansen

Health Care Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Mådløv, Denmark

John Bondo Hansen

Health Care Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Mådløv, Denmark

Erik B. Nielsen

Health Care Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Mådløv, Denmark

The effect of 'typical' and 'atypical' neuroleptics on interstitial levels of the dopamine metabolite 3,4- dihydroxyphenylacetic acid ([DOPAC]e) in the dorsolateral striatum (DLSt), the nucleus accumbens (NAc) and the medial prefrontal cortex (PFC) was investigated in awake rats by use of the microdialysis technique. All neuroleptics increased [DOPAC]e in the DLSt, NAc and in PFC. However, the 'atypical' neuroleptics clozapine, risperidone, sertindole and NNC 22-0031 showed an apparent cortical selectivity by preferentially elevating [DOPAC]e in the PFC compared with the DLSt and NAc, a feature which was not observed with the 'typical' neuroleptic haloperidol. Our data suggest that 'atypical' neuroleptics can be differentiated from the 'typical' neuroleptic, haloperidol, with respect to their ability to increase [DOPAC]e in PFC relative to DLSt and NAc.

Key Words: microdialysis • 3,4-dihydroxyphenylacetic acid (DOPAC) • neuroleptics • prefrontal cortex • dorsolateral striatum • nucleus accumbens

Journal of Psychopharmacology, Vol. 10, No. 2, 119-125 (1996)
DOI: 10.1177/026988119601000206
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement