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The effect of metergoline on endocrine responses to L-tryptophan

MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Research Unit, Littlemore Hospital, Littlemore, Oxford OX4 4XN

P.J. Cowen

MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Research Unit, Littlemore Hospital, Littlemore, Oxford OX4 4XN

H. Waller

MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Research Unit, Littlemore Hospital, Littlemore, Oxford OX4 4XN

D.G. Grahame-Smith

MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Research Unit, Littlemore Hospital, Littlemore, Oxford OX4 4XN

The effects of the 5-HT receptor antagonist, metergoline, on the prolactin and growth hormone responses to intravenous L-tryptophan were assessed in seven normal subjects. Pretreatment with metergoline lowered baseline prolactin concentration and abol ished the increase in prolactin following L-tryptophan. In contrast, neither baseline nor the response to L-tryptophan was altered by metergoline. These results are consistent with the proposal that the prolactin response to L-tryptophan is mediated by 5-HT₁ receptors; however, metergoline might also reduce prolactin responses by a dopaminergic action. The nature of the 5-HT receptor involved in the growth hormone response to L-tryptophan remains to be identified.

Journal of Psychopharmacology, Vol. 1, No. 2, 90-94 (1987)
DOI: 10.1177/026988118700100205


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