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The effects of single doses of alpidem and lorazepam on memory and psychomotor performance in normal humans

Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF

David Allen

Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF

Malcolm Lader

Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF

Two studies are reported which compare different single doses of alpidem (SL80.0343-00) with lorazepam 2 mg. In the first study, lorazepam and the highest (100 mg) dose of alpidem impaired performance on a range of psychomotor tasks, although the effects of lorazepam were more severe and persisted for longer than those of alpidem. In comparison, alpidem 50 and 25 mg had little effect. The EEG profiles of both drugs were similar.

Journal of Psychopharmacology, Vol. 1, No. 2, 81-89 (1987)
DOI: 10.1177/026988118700100204


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