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DOI: 10.1177/026988118700100208 The psychopharmacology of the human pinealInstitute of Psychiatry, London
Institute of Psychiatry, London
In many ways the pineal is an ideal endocrine gland for the biological psychiatrist. The gland is small, circumscribed and relatively homogeneous, so it can be studied either in tissue culture or in vivo. The results from such studies combine to give a well-characterized model for investigating noradrenergic neurotransmission. In the pineal as in the brain there is a noradrenaline uptake site, an autoreceptor which regulates noradrenaline release, and there are post-junctional ß1 and
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1-adrenoceptors. In the pineal as in the brain the ß1 adrenoceptor is linked to adenylate cyclase and the