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Journal of Psychopharmacology, Vol. 1, No. 1, 20-22 (1987)
DOI: 10.1177/026988118700100105

Effects of a phosphodiesterase inhibitor (Rolipram) on the urinary excretion of 6-sulphatoxy melatonin in man

S.A. Checkley

Maudsley Hospital, Denmark Hill, London, SE5

F. Winton

Maudsley Hospital, Denmark Hill, London, SE5

T. Corn

Maudsley Hospital, Denmark Hill, London, SE5

C. Franey

University of Surrey, Guildford, Surrey

J. Arendt

University of Surrey, Guildford, Surrey

The urinary excretion of 6-sulphatoxymelatonin (aMT6s) from 2400 to 0600 h was significantly increased following the treatment of ten normal volunteers with a phospho diesterase inhibitor (rolipram 1 mg 8 h for 24 h). The urinary excretion of the metabolite from 0600 to 1200 h was significantly reduced after treatment with rolipram.


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