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Journal of Psychopharmacology
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Article

Nabilone produces marked impairments to cognitive function and changes in subjective state in healthy volunteers

KA Wesnes1, P Annas2, CJ Edgar3*, C Deeprose1, R Karlsten2, A Philipp4, J Kalliomäki2, and M Segerdahl2

1 Cognitive Drug Research Ltd., Goring-on-Thames, UK
2 Astra Zeneca R&D, Södertälje, Sweden
3 Consultant Psychologist, Reading, UK
4 ICON plc, Dublin, Ireland

* To whom correspondence should be addressed.


  Abstract

Abstract

This was a double-blind, randomised, placebo-controlled, crossover study of the acute cognitive and subjective effects of nabilone 1–3 mg in healthy male volunteers. The Cognitive Drug Research computerised system (CDR system) was used to assess changes in attention, working and episodic memory. In addition, a number of self-ratings were conducted including those of mood, alertness and perceived drug effects. Impairments to attention, working and episodic memory and self-ratings of alertness were evident. Volunteers also experienced a number of subjective drug effects. These data demonstrate that acute doses of nabilone in the range 1–3 mg produce clear cognitive and subjective effects in healthy volunteers, and therefore they may be used as reference data in the future study of peripherally acting cannabinoids believed to be free from such effects.

Key Words: attention, CDR system, cognition, episodic memory, nabilone, subjective effects, working memory

First published on June 12, 2009
Journal of Psychopharmacology 2009, doi:10.1177/0269881109105900
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